Cilostazol is a specialized type-3 phosphodiesterase (PDE3) inhibitor that provides a dual mechanism of antiplatelet activity and smooth muscle relaxation. By selectively preventing the breakdown of cyclic adenosine monophosphate (cAMP) inside blood vessels and platelets, it significantly increases intracellular cAMP levels. This biological pathway directly induces arterial vasodilation, inhibits platelet activation, improves lower-limb micro-circulation, and effectively relieves ischemic leg pain during movement.